Talks for speakers are 20 min + 5 min discussion
Keynote speakers: 50 min plus 10 min discussion
Day 1 : Sunday 29
Registration 16.00 to 18.00
18.00 Introductory remarks
Keynote lecture
18.15-19.15. Cedric Blanpain: The role of Sox transcription factors in regulating tumor heterogeneity.
Dinner and free evening discussions
Day 2 : Monday 30
7.00-8.45 am. Breakfast
Session 1: Evolution - Structure – Function (8.45-12.05)
Chairs: Lukas Sommer + Elisabeth Sock
- 8.45-9.10. Michael Weiss: Biochemical tinkering and hopeful monsters in the evolution of SRY
- 9.10-9.35. Jeremy Prokop: Evolutionary Landscape of SOX Genes to build a System Approach to Inform Genotype-to-Phenotype Relationships
- 9.35-10.00. Alistair McGregor: Spiders have many Sox: Characterization of the expression and function of Sox genes in the spider Parasteatoda tepidariorum and other arachnids
- 10.00-10.25. Steve Russell: Group B in insect segmentation and CNS development
10.25-10.50 coffee break
- 10.50-11.15. Ralf Jauch: Programming cell fates with artificially evolved Sox transcription factors
- 11.15-11.40. Kathryn Cheah: Molecular insights into mechanisms of campomelic dysplasia caused by the SOX9Y440Xmutation
- 11.40-12.05. Carole LaBonne: Changing Sox: Roles of SoxB1 and SoxE Transcription Factors in the Evolution of a GRN Controlling Pluripotency and Neural Crest formation.
- 12.05-12.30. Mathias Francois: Deciphering the mechanism of SOX18 search pattern on the chromatin uncovers the molecular aetiology of a rare vascular disorder.
12.30 lunch
Session 2: SOX and Stem Cells (14.00-17.00)
Chairs: Peter Koopman + Carole LaBonne
- 14.00-14.25. Hisato Kondoh: Changing SOX2 partners during the developmental progression of stem cells
- 14.25-14.50. Sergiy Velychko: Breaking reprogramming barriers by enhancing Oct-Sox cooperativity
- 14.50-15.15. Walfred Tang: The critical role of SOX17 in human germline development
- 15.15-15.40. Freddy Wong: SOX17 couples with OCT4 to initiate human PGC specification
15:40-16.10 coffee break
- 16.10-16.35. Aixa Morales: From Quiescence to proliferation and back: The active Life of Neural Stem Cells.
- 16.35-17.00. Silvia Kirsten Nicolis: Sox2 shapes 3D functional genome architecture in brain-derived neural stem cells
Session 3: Soxs and Pathologies (17.00-17.50)
Chairs: Kathy Cheah + Mathias Francois
- 17.00-17.25. Veronique Lefebvre: SOXopathies: a growing family of developmental disorders due to SOX mutations
- 17.25-17.50. Monica Beltrame: Defining SoxF regulatory networks in vascular and lymphatic development in zebrafish
Dinner and discussions
19.30 Poster Session (open end)
Day 3. Tuesday 01
7.00-8.45 am. Breakfast
Session 3: Soxs and Pathologies (continued) (8.45-12.30)
Chairs: Kathy Cheah + Mathias Francois
- 8.45-9.10. Chris Lau: The Roles of the Y-Located SRY Gene in Sex Differences in Health and Diseases
- 9.10-9.35. Marco Angelozzi: Intramembranous bone formation critically relies on SOXC expression in progenitor cells
- 9.35-10.00. Dawei Sun: Investigating SOX2 and SOX9 function in human fetal lung progenitor cells.
- 10.00-10.25. Robert Kelsh: Sox10 and fate specification of neural crest-derived pigment cells-the cellular environment
10.25-10.50 coffee break
- 10.50-11.15. Masami Kanai-Azuma: Defects in the early crypt formation of the uterine epithelia in Sox17 heterozygous mice
- 11.15-11.40. Yoshiakira Kanai: Gallbladder Wall Abnormality in Biliary Atresia of Mouse Sox17+/- Neonates and Human Infants
- 11.40-12.05. Vince Harley: A gene only in males contributes to male bias in experimental PD
- 12.05-12.30. Hiroshi Asahara: Characterization of a novel Sox9 enhancer and down-stream targets with implications in Arthritis parthenogenesis and therapeutics.
12.30 lunch
13.30 Excursion
20.30 Gala dinner and party
Day 4. Wednesday 02
7.00-8.45 am. Breakfast
Session 4: Sex determination and Sexual Differentiation (8.30-12.05)
Chairs: Vince Harley + Masai Kanai-Azuma
- 8.45-9.10. Peter Koopman: Going nuts: SRY function in sex determination
- 9.10-9.35. Robin Lovell-Badge: The regulation of Sox9 during gonadal development
- 9.35-10.00. Andrew Sinclair: Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9
- 10.00-10.25. Dagmar Wilhelm: Sex with one Sox
10.25-10.50 coffee break
- 10.50-11.15. Marie-Christine Chaboissier: Female-to-male sex reversal is driven by different Sox genes.
- 11.15-11.40. Francis Poulat: Relationships between SOX9 and Trim28
- 11.40-12.05. Andrew Pask: SOX9 shows a rapid response to oestrogen in humans
12.30 Lunch
Session 5: Neuronal Development (14.00-12.00)
Chairs: Steve Russel + Karine Rizzoti
- 14.00-14.25. Mercurio Sara: Sox2 expression in thalamic neurons is required for the development of the visual system
- 14.25-14.50. Elena Silva: Neurogenesis and disease driven by varying Sox11 protein interactions
- 14.50-15.15. Alessia Caramello: Region-specific roles of SOX9 during brain neuroepithelial progenitor cell fate acquisition
- 15.15-15.40. Ann Morris: Exploring the role of SoxC factors in eye development: novel insights from zebrafish
15.40-16.10 coffee break
- 15.40-16.05. Michael Wegner: Sox10 and transcriptional control in myelinating glia
- 16.05-16.30. Christophe Galichet: Proliferation and differentiation of Median Eminence Oligodendrocyte Precursor Cells is required for normal function ofthe hypothalamo-pituitary axis
- 16.30-16.55. Li-Jin Chew: Sox17 regulates Notch during the development and regeneration of white matter Oligodendrocytes
16.30h Steering committee discussions (closed)
Dinner and free evening discussions
Day 5. Thursday 03
7.00-8.45 am. Breakfast
Session 6: SOXs in Tissue Homeostasis, Repair and Cancer (8.45-11.15)
Chairs: Veronique Lefebvre + Michael Wegner
- 8.45-9.10. Martin Cheung: Targeting SOX9 expression in human neural stem cells is a therapeutic strategy for spinal cord injury
- 9.10-9.35. Lukas Sommer: The Role of Injury-Activated Glia in Wound Healing
- 9.35-10.00. Karine Rizzoti: Functional characterization of the interaction between SOX2 and p27KIP1 during tumorigenesis.
10.00 -10.25 coffee break
- 10.25-10.50. Sabine Stöckl: The role of Sox9 in chondrosarcoma
- 10.50-11.15. Carlos Moreno: SOX4 regulates invasion of bladder cancer cells via repression of WNT5a
- 11.15-11.35. Jonas Muhr: SOX21 is Required for the Activation of Antitumorigenic Responses in Neural Stem Cells
The future of SOX & closing remarks: Peter Koopman, Francis Poulat, Andreas Schedl